c-LEcta Announces Launch of GMP Grade DENARASE High Salt
Leipzig, Germany, 25th March 2025 – c-LEcta, a leading international supplier of enzymes for the biopharmaceutical industry, proudly announces the launch of the GMP-grade version of DENARASE High Salt, a strategic extension of its DENARASE portfolio. Following the launch of the R&D grade in March 2024, DENARASE High Salt is now also available as GMP-grade, intended to serve customers with clinical and commercial stage processes that require compliance with the highest quality standards.
Revolutionary Engineering for Enhanced Biomanufacturing
DENARASE and DENARASE High Salt are recombinantly produced Serratia marcescens endonucleases utilized for the removal of DNA/RNA impurities in biopharmaceutical production. DENARASE High Salt is an engineered version of c-LEcta’s top-selling product DENARASE and was designed for improved salt and pH tolerance, enabling customers more flexibility in process development. Minor (targeted) modifications to the enzyme's surface have enhanced its salt tolerance while maintaining compatibility with existing ELISA kits for residual monitoring of Serratia marcescens endonucleases.
High Quality Standards for Streamlined Manufacturing Processes
The launch of DENARASE High Salt GMP-grade marks a significant milestone in c-LEcta’s commitment to providing innovative solutions for the biopharmaceutical industry. This engineered enzyme efficiently and cost-effectively removes nucleic acids in biomanufacturing processes that benefit from elevated salt levels. Key applications include:
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Viral Vectors for Cell & Gene Therapies
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Viral Vaccines
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Viscosity reduction in Lysates
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Sample preparation in Electrophoresis and Chromatography.
Empowering Biopharmaceutical Innovation
DENARASE High Salt GMP-grade complements c-LEcta’s offering for efficient DNA/RNA removal, encompassing various qualities and packaging sizes of DENARASE enzymes and ELISA Kits. By expanding the DENARASE portfolio, c-LEcta empowers its customers to streamline workflows, achieve consistent high-quality outcomes, and drive advancements in viral vector manufacturing forward.
For more information about DENARASE High Salt GMP-grade and other c-LEcta products, please visit www.denarase.com.
About c-LEcta
c-LEcta is a global biotechnology company specializing in the development, production and distribution of enzyme products. The company uses world-class enzyme engineering and production technologies to provide its partners in the food and pharmaceutical industries with superior biotechnological solutions for innovative industrial applications. Product development is based on the proprietary enzyme technology platform ENESYZ® and is carried out both in-house and in close cooperation with industry partners worldwide. c-LEcta supplies its products to more than 400 customers in over 40 countries. c-LEcta currently employs more than 130 people at its headquarters in Leipzig.
c-LEcta is part of the Kerry Group. Kerry is aworld leading taste and nutrition partner for the food, beverage and pharmaceutical sectors.